InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: P2RY6

Summary

InnateDB Gene

IDBG-63719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

P2RY6

Gene Name

pyrimidinergic receptor P2Y, G-protein coupled, 6

Synonyms

P2Y6

Species

Homo sapiens

Ensembl Gene

ENSG00000171631

Encoded Proteins

IDBP-63721

pyrimidinergic receptor P2Y, G-protein coupled, 6

IDBP-243308

pyrimidinergic receptor P2Y, G-protein coupled, 6

IDBP-243310

pyrimidinergic receptor P2Y, G-protein coupled, 6

IDBP-243312

pyrimidinergic receptor P2Y, G-protein coupled, 6

IDBP-599149

pyrimidinergic receptor P2Y, G-protein coupled, 6

IDBP-586332

pyrimidinergic receptor P2Y, G-protein coupled, 6

IDBP-596762

pyrimidinergic receptor P2Y, G-protein coupled, 6

IDBP-596184

pyrimidinergic receptor P2Y, G-protein coupled, 6

IDBP-586987

pyrimidinergic receptor P2Y, G-protein coupled, 6

IDBP-587758

pyrimidinergic receptor P2Y, G-protein coupled, 6

IDBP-596837

pyrimidinergic receptor P2Y, G-protein coupled, 6

IDBP-806707

pyrimidinergic receptor P2Y, G-protein coupled, 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. Four transcript variants encoding the same isoform have been identified for this gene. [provided by RefSeq, Jul 2008]
The product of this gene belongs to the family of P2 receptors, which is activated by extracellular nucleotides and subdivided into P2X ligand-gated ion channels and P2Y G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor, which is a G-protein coupled receptor, is responsive to UDP, partially responsive to UTP and ADP, and not responsive to ATP. It is proposed that this receptor mediates inflammatory responses. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Mar 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:73264505-73298617

Strand

Forward strand

Band

q13.4

Transcripts

ENST00000349767	ENSP00000309771
ENST00000393592	ENSP00000377217
ENST00000393591	ENSP00000377216
ENST00000393590	ENSP00000377215
ENST00000540342	ENSP00000443427
ENST00000542092	ENSP00000445652
ENST00000544437	ENSP00000441079
ENST00000540124	ENSP00000442551
ENST00000536225	ENSP00000442509
ENST00000535931	ENSP00000440770
ENST00000538328	ENSP00000442990
ENST00000618468	ENSP00000480966

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004930	G-protein coupled receptor activity
GO:0045028	G-protein coupled purinergic nucleotide receptor activity
GO:0045029	UDP-activated nucleotide receptor activity

Biological Process

GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0014911	positive regulation of smooth muscle cell migration
GO:0030321	transepithelial chloride transport
GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane