InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: MMP14

Summary

InnateDB Protein

IDBP-599184.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MMP14

Protein Name

matrix metallopeptidase 14 (membrane-inserted)

Synonyms

MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; WNCHRS;

Species

Homo sapiens

Ensembl Protein

ENSP00000446989

InnateDB Gene

IDBG-2848 (MMP14)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	27 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0008270	zinc ion binding

Biological Process

GO:0006508	proteolysis
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration

Cellular Component

GO:0031012

extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR001818 Peptidase M10, metallopeptidase
IPR002477 Peptidoglycan binding-like
IPR021190 Peptidase M10A

PFAM

PF00413
PF01471

PRINTS

PR00138

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F8W1B7

UniProt Splice Variant

Entrez Gene

4323

UniGene

Hs.2399

RefSeq

HUGO

HGNC:7160

OMIM

600754

CCDS

HPRD

02856

IMGT

EMBL

AL135998

GenPept