InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PEX11B

Summary

InnateDB Protein

IDBP-599451.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PEX11B

Protein Name

peroxisomal biogenesis factor 11 beta

Synonyms

PEX11-BETA; PEX14B;

Species

Homo sapiens

Ensembl Protein

ENSP00000437510

InnateDB Gene

IDBG-101742 (PEX11B)

Protein Structure

UniProt Annotation

Function

Involved in peroxisomal proliferation. May regulate peroxisomes division by recruiting the dynamin-related GTPase DNM1L to the peroxisomal membrane. {ECO:0000269PubMed:12618434, ECO:0000269PubMed:9792670}.

Subcellular Localization

Peroxisome membrane {ECO:0000269PubMed:10704444, ECO:0000269PubMed:9792670, ECO:0000269PubMed:9826565}; Single-pass membrane protein {ECO:0000269PubMed:10704444, ECO:0000269PubMed:9792670, ECO:0000269PubMed:9826565}.

Disease Associations

Peroxisome biogenesis disorder 14B (PBD14B) [MIM:614920]: An autosomal recessive peroxisome biogenesis disorder characterized clinically by mild intellectual disability, congenital cataracts, progressive hearing loss, and polyneuropathy. Additionally, recurrent migraine-like episodes following mental stress or physical exertion, not a common feature in peroxisome disorders, are observed. {ECO:0000269PubMed:22581968}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	9 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	2 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0007031	peroxisome organization
GO:0007165	signal transduction
GO:0016559	peroxisome fission
GO:0044375	regulation of peroxisome size
GO:0051260	protein homooligomerization

Cellular Component

GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005779	integral component of peroxisomal membrane
GO:0016020	membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome