InnateDB Protein
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IDBP-599617.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HPD
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Protein Name
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4-hydroxyphenylpyruvate dioxygenase
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Synonyms
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4-HPPD; 4HPPD; GLOD3; HPPDASE; PPD;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000441677
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InnateDB Gene
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IDBG-62008 (HPD)
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Protein Structure
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Function |
Key enzyme in the degradation of tyrosine.
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Subcellular Localization |
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Disease Associations |
Tyrosinemia 3 (TYRSN3) [MIM:276710]: An inborn error of metabolism characterized by elevations of tyrosine in the blood and urine, seizures and mild mental retardation. {ECO:0000269PubMed:10942115, ECO:0000269PubMed:11073718}. Note=The disease is caused by mutations affecting the gene represented in this entry.Hawkinsinuria (HAWK) [MIM:140350]: An inborn error of tyrosine metabolism characterized by failure to thrive, persistent metabolic acidosis, fine and sparse hair, and excretion of the unusual cyclic amino acid metabolite, hawkinsin, in the urine. {ECO:0000269PubMed:11073718}. Note=The disease is caused by mutations affecting the gene represented in this entry.
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
5
[view]
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Protein-Protein |
5
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003868
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4-hydroxyphenylpyruvate dioxygenase activity
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GO:0016701
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oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
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GO:0046872
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metal ion binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR004360
Glyoxalase/fosfomycin resistance/dioxygenase domain
IPR005956
4-hydroxyphenylpyruvate dioxygenase
IPR029068
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
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PFAM |
PF00903
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PRINTS |
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PIRSF |
PIRSF009283
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P32754
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PhosphoSite |
PhosphoSite-P32754
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
3242
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UniGene |
Hs.2899
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RefSeq |
NP_001165464
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HUGO |
HGNC:5147
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OMIM |
609695
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CCDS |
CCDS53839
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HPRD |
02041
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IMGT |
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EMBL |
AC069503
AC079360
AK057510
AK290826
BC024287
CH471054
D31628
U29895
X72389
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GenPept |
AAC73008
AAH24287
BAA06498
BAF83515
BAG51925
CAA51082
EAW98292
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