InnateDB Protein
|
IDBP-599844.3
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
THEMIS
|
Protein Name
|
thymocyte selection associated
|
Synonyms
|
|
Species
|
Homo sapiens
|
Ensembl Protein
|
ENSP00000439863
|
InnateDB Gene
|
IDBG-96262 (THEMIS)
|
Protein Structure
|
|
Function |
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity). {ECO:0000250}.
|
Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
|
Disease Associations |
|
Tissue Specificity |
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
4 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
|
InterPro |
|
PFAM |
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
Q8N1K5
|
PhosphoSite |
PhosphoSite-Q8N1K5
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
387357
|
UniGene |
Hs.661756
|
RefSeq |
NP_001158159
|
HUGO |
HGNC:21569
|
OMIM |
613607
|
CCDS |
CCDS55055
|
HPRD |
16662
|
IMGT |
|
EMBL |
AK094863
AK097903
AK124031
AK128377
AK292046
AL035470
AL356432
AL365224
BC130516
BX640890
CH471051
|
GenPept |
AAI30517
BAC05194
BAF84735
BAG52943
BAG53994
BAG54669
CAE45941
CAI13396
CAI13397
CAI17110
CAI17111
EAW48092
|
|
|