Version 5.4
Homo sapiens Gene: THEMIS
Summary
InnateDB Gene IDBG-96262.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol THEMIS
Gene Name thymocyte selection associated
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172673
Encoded Proteins
IDBP-96266
thymocyte selection associated
IDBP-96268
thymocyte selection associated
IDBP-386805
thymocyte selection associated
IDBP-599844
thymocyte selection associated
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:127708072-127918631
Strand Reverse strand
Band q22.33
Transcripts
ENST00000368250 ENSP00000357233
ENST00000368248 ENSP00000357231
ENST00000434358 ENSP00000387740
ENST00000537166 ENSP00000439863
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0043368 positive T cell selection
GO:0043383 negative T cell selection
GO:0050852 T cell receptor signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0008180 COP9 signalosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049109
View Gene Order
ENSBTAG00000015615
Not yet available
Cross-References
SwissProt
TrEMBL X1WI26
UniProt Splice Variant
Entrez Gene 387357
UniGene Hs.661756
RefSeq NM_001010923 NM_001164685 NM_001164687 XM_005266974 XM_006715476 XM_006725017 XM_006725018
HUGO HGNC:21569
OMIM 613607
CCDS CCDS34534 CCDS55055
HPRD 16662
IMGT
EMBL AL035470 AL356432 AL365224
GenPept
RNA Seq Atlas 387357

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca