Version 5.4
Homo sapiens Protein: VAMP4
Summary
InnateDB Protein IDBP-599886.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VAMP4
Protein Name vesicle-associated membrane protein 4
Synonyms VAMP-4; VAMP24;
Species Homo sapiens
Ensembl Protein ENSP00000435933
InnateDB Gene IDBG-104804 (VAMP4)
Protein Structure
UniProt Annotation
Function Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule.
Subcellular Localization Golgi apparatus, trans-Golgi network membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Note=Associated with trans Golgi network (TGN) and newly formed immature secretory granules (ISG). Not found on the mature secretory organelles.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 17 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0016192 vesicle-mediated transport
GO:0035493 SNARE complex assembly
Cellular Component
GO:0000139 Golgi membrane
GO:0005764 lysosome
GO:0005768 endosome
GO:0009986 cell surface
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR001388 Synaptobrevin
PFAM PF00957
PRINTS PR00219
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O75379
PhosphoSite PhosphoSite-O75379
TrEMBL Q6IAZ3
UniProt Splice Variant
Entrez Gene 8674
UniGene Hs.6651
RefSeq
HUGO HGNC:12645
OMIM 606909
CCDS CCDS1298
HPRD 06070
IMGT
EMBL AF044310 AK290441 AL035296 BC005974 BC007019 BC031264 CH471067 CR457011 Z98751
GenPept AAC24032 AAH05974 AAH07019 AAH31264 BAF83130 CAA22896 CAG33292 CAM28272 EAW90904 EAW90905 EAW90908

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca