InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CUL7

Summary

InnateDB Protein

IDBP-599993.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CUL7

Protein Name

cullin 7

Synonyms

3M1; dJ20C7.5; KIAA0076;

Species

Homo sapiens

Ensembl Protein

ENSP00000438788

InnateDB Gene

IDBG-87630 (CUL7)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0000281	mitotic cytokinesis
GO:0001570	vasculogenesis
GO:0001837	epithelial to mesenchymal transition
GO:0001890	placenta development
GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0006987	activation of signaling protein activity involved in unfolded protein response
GO:0007030	Golgi organization
GO:0007088	regulation of mitosis
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0044267	cellular protein metabolic process
GO:0050775	positive regulation of dendrite morphogenesis

Cellular Component

GO:0005634	nucleus
GO:0005680	anaphase-promoting complex
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005813	centrosome
GO:0005829	cytosol
GO:0031461	cullin-RING ubiquitin ligase complex
GO:0031467	Cul7-RING ubiquitin ligase complex
GO:0048471	perinuclear region of cytoplasm
GO:1990393	3M complex

Protein Structure and Domains

PDB ID

InterPro

IPR001373 Cullin, N-terminal
IPR004939 Anaphase-promoting complex, subunit 10/DOC domain
IPR008979 Galactose-binding domain-like
IPR016024 Armadillo-type fold
IPR016158 Cullin homology
IPR019559 Cullin protein, neddylation domain
IPR021097 CPH domain

PFAM

PF00888
PF03256
PF10557
PF11515

PRINTS

PIRSF

SMART

SM00182
SM00884

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14999