InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TLR5

Summary

InnateDB Protein

IDBP-600027.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TLR5

Protein Name

toll-like receptor 5

Synonyms

MELIOS; SLE1; SLEB1; TIL3;

Species

Homo sapiens

Ensembl Protein

ENSP00000440643

InnateDB Gene

IDBG-106840 (TLR5)

Protein Structure

UniProt Annotation

Function

Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. {ECO:0000269PubMed:11323673}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Systemic lupus erythematosus 1 (SLEB1) [MIM:601744]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Tissue Specificity

Highly expressed in ovary and in peripheral blood leukocytes, especially in monocytes, less in CD11c+ immature dendritic cells. Also detected in prostate and testis.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.

Experimentally validated
Total	11 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0005149	interleukin-1 receptor binding
GO:0005515	protein binding

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006954	inflammatory response
GO:0007165	signal transduction
GO:0008584	male gonad development
GO:0032757	positive regulation of interleukin-8 production
GO:0034123	positive regulation of toll-like receptor signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0042742	defense response to bacterium
GO:0045087	innate immune response (InnateDB)
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0050707	regulation of cytokine secretion
GO:0071222	cellular response to lipopolysaccharide
GO:0071260	cellular response to mechanical stimulus

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000157 Toll/interleukin-1 receptor homology (TIR) domain
IPR000483 Cysteine-rich flanking region, C-terminal
IPR001611 Leucine-rich repeat
IPR003591 Leucine-rich repeat, typical subtype

PFAM

PF01582
PF13676
PF01463
PF00560
PF13504
PF13855

PRINTS

PIRSF

SMART

SM00255
SM00082
SM00369

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O60602