Version 5.4
| Homo sapiens Gene: TLR5 | |||||||||||||||||||||||||||||||
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| Summary | |||||||||||||||||||||||||||||||
| InnateDB Gene | IDBG-106840.6 | ||||||||||||||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||
| Gene Symbol | TLR5 | ||||||||||||||||||||||||||||||
| Gene Name | toll-like receptor 5 | ||||||||||||||||||||||||||||||
| Synonyms | MELIOS; SLE1; SLEB1; TIL3 | ||||||||||||||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||||||||||||||
| Ensembl Gene | ENSG00000187554 | ||||||||||||||||||||||||||||||
| Encoded Proteins |
toll-like receptor 5
toll-like receptor 5
toll-like receptor 5
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| Protein Structure | |||||||||||||||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||||||||||||||
| Summary |
TLR5 engagement with its ligand, flagellin, results in the activation of MAP kinases (ERK1/2, JNK, and p38) and degradation of NFKBIA (I-kappa-B-alpha).
Toll-like receptor 5 (TLR5) is the TLR activated by bacterial flagellin and TLR5 residue 268 is responsible for human and mouse discrimination between flagellin molecules.
TLR5 recognizes bacterial flagellin from both Gram-positive and Gram-negative bacteria, and its activation mobilizes the nuclear factor NF-kappaB and stimulates tumour necrosis factor-alpha (TNF) production.
TLR5 expressed on the basolateral surface of intestinal epithelia mediates innate immune inflammatory responses to Salmonella by inducing epithelial pro-inflammatory gene expression.
TLR5 forms heteromeric complexes with TLR4 as well as homomeric complexes. Signaling via heteromeric TLR5/TLR4 complexes is involved in the induction of macrophage nitric oxide (NO) production by Gram-negative flagellin.
TLR5 forms a dimer upon binding to bacterial flagellin.
TLR5 is highly expressed in mucosal dendritic cells and TLR5 signalling restricts regulatory T cell generation. (Demonstrated in mice)
TLR5 deficiency in mice leads to a transient inability to manage proteobacteria which promotes chronic gut inflammation. (Demonstrated in mouse)
CXCR1 regulates anti-Pseudomonas neutrophil responses through modulation of reactive oxygen species and interference with TLR5 expression.
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| InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||
| Summary |
[Mus musculus] Tlr5 forms a dimer upon binding to bacterial flagellin. (Demonstrated in human)
[Mus musculus] Tlr5 is highly expressed in mucosal dendritic cells and Tlr5 signalling restricts regulatory T cell generation.
[Mus musculus] Tlr5 deficiency in mice leads to a transient inability to manage proteobacteria which promotes chronic gut inflammation.
[Mus musculus] Flagellin-specific IgG1 antibody response is induced through a Tlr5-, inflammasome-, and Myd88-independent pathway.
[Mus musculus] Flagellin induces Tlr5-dependent Il22 production and Nlrc4-dependent Il18 production to promote a protective gene expression program in intestinal epithelial cells and elimination of rotavirus-infected cells.
[Mus musculus] Indirect Tlr5-dependent stimulation of airway conventional dendritic cells is essential to flagellin's mucosal adjuvant activity.
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| Entrez Gene | |||||||||||||||||||||||||||||||
| Summary |
This gene encodes a member of the toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immune responses. These receptors recognize distinct pathogen-associated molecular patterns that are expressed on infectious agents. The protein encoded by this gene recognizes bacterial flagellin, the principal component of bacterial flagella and a virulence factor. The activation of this receptor mobilizes the nuclear factor NF-kappaB, which in turn activates a host of inflammatory-related target genes. Mutations in this gene have been associated with both resistance and susceptibility to systemic lupus erythematosus, and susceptibility to Legionnaire disease.[provided by RefSeq, Dec 2009] |
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| Gene Information | |||||||||||||||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||||||||||||||
| Genomic Location | Chromosome 1:223109406-223143282 | ||||||||||||||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||||||||||||||
| Band | q41 | ||||||||||||||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||||||||||||||
| NETPATH | |||||||||||||||||||||||||||||||
| REACTOME |
MyD88 cascade initiated on plasma membrane pathway
Toll Like Receptor 10 (TLR10) Cascade pathway
Toll Like Receptor 5 (TLR5) Cascade pathway
Innate Immune System pathway
Toll-Like Receptors Cascades pathway
Immune System pathway
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| KEGG |
Pathogenic Escherichia coli infection pathway
Toll-like receptor signaling pathway pathway
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| INOH | |||||||||||||||||||||||||||||||
| PID NCI | |||||||||||||||||||||||||||||||
| Cross-References | |||||||||||||||||||||||||||||||
| SwissProt | |||||||||||||||||||||||||||||||
| TrEMBL | |||||||||||||||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||||||||||||||
| Entrez Gene | |||||||||||||||||||||||||||||||
| UniGene | Hs.150756 Hs.604542 | ||||||||||||||||||||||||||||||
| RefSeq | NM_003268 XM_005273241 XM_005273242 XM_005273243 XM_006711503 XM_006711504 XM_006711505 XM_006711506 XM_006711507 | ||||||||||||||||||||||||||||||
| HUGO | |||||||||||||||||||||||||||||||
| OMIM | |||||||||||||||||||||||||||||||
| CCDS | CCDS31033 | ||||||||||||||||||||||||||||||
| HPRD | 04326 | ||||||||||||||||||||||||||||||
| IMGT | |||||||||||||||||||||||||||||||
| EMBL | |||||||||||||||||||||||||||||||
| GenPept | |||||||||||||||||||||||||||||||
| RNA Seq Atlas | |||||||||||||||||||||||||||||||