Homo sapiens Protein: LATS1 | |||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||
InnateDB Protein | IDBP-600043.3 | ||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||
Gene Symbol | LATS1 | ||||||||||||||||||||||||||||
Protein Name | LATS, large tumor suppressor, homolog 1 (Drosophila) | ||||||||||||||||||||||||||||
Synonyms | WARTS; wts; | ||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||
Ensembl Protein | ENSP00000437550 | ||||||||||||||||||||||||||||
InnateDB Gene | IDBG-97771 (LATS1) | ||||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||||||||
Function | Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. {ECO:0000269PubMed:10518011, ECO:0000269PubMed:10831611, ECO:0000269PubMed:15122335, ECO:0000269PubMed:15220930, ECO:0000269PubMed:18158288, ECO:0000269PubMed:19927127}. | ||||||||||||||||||||||||||||
Subcellular Localization | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:10518011}. Note=Localizes to the centrosomes throughout interphase but migrates to the mitotic apparatus, including spindle pole bodies, mitotic spindle, and midbody, during mitosis. | ||||||||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||||||||
Tissue Specificity | Expressed in all adult tissues examined except for lung and kidney. {ECO:0000269PubMed:10518011}. | ||||||||||||||||||||||||||||
Comments | |||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||||||||
PDB ID | |||||||||||||||||||||||||||||
InterPro |
IPR000449
Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal IPR000719 Protein kinase domain IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain IPR009060 UBA-like IPR011009 Protein kinase-like domain IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote IPR017892 Protein kinase, C-terminal IPR020635 Tyrosine-protein kinase, catalytic domain |
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PFAM |
PF00627
PF00069 PF07714 PF00433 |
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PRINTS |
PR00109
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PIRSF | |||||||||||||||||||||||||||||
SMART |
SM00220
SM00165 SM00219 |
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TIGRFAMs | |||||||||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||||||||
Modification | |||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||
SwissProt | O95835 | ||||||||||||||||||||||||||||
PhosphoSite | PhosphoSite-O95835 | ||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||
Entrez Gene | 9113 | ||||||||||||||||||||||||||||
UniGene | Hs.633030 | ||||||||||||||||||||||||||||
RefSeq | NP_004681 | ||||||||||||||||||||||||||||
HUGO | HGNC:6514 | ||||||||||||||||||||||||||||
OMIM | 603473 | ||||||||||||||||||||||||||||
CCDS | CCDS34551 | ||||||||||||||||||||||||||||
HPRD | 09147 | ||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||
EMBL | AF104413 AF164041 BC002767 | ||||||||||||||||||||||||||||
GenPept | AAD16882 AAD50272 AAH02767 | ||||||||||||||||||||||||||||