InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRSF6

Summary

InnateDB Protein

IDBP-600062.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF6

Protein Name

serine/arginine-rich splicing factor 6

Synonyms

B52; HEL-S-91; SFRS6; SRP55;

Species

Homo sapiens

Ensembl Protein

ENSP00000433544

InnateDB Gene

IDBG-75761 (SRSF6)

Protein Structure

UniProt Annotation

Function

Plays a role in constitutive splicing and modulates the selection of alternative splice sites. Plays a role in the alternative splicing of MAPT/Tau exon 10. Binds to alternative exons of TNC pre-mRNA and promotes the expression of alternatively spliced TNC. Plays a role in wound healing and in the regulation of keratinocyte differentiation and proliferation via its role in alternative splicing. {ECO:0000269PubMed:12549914, ECO:0000269PubMed:15009664, ECO:0000269PubMed:22767602, ECO:0000269PubMed:24440982}.

Subcellular Localization

Nucleus. Nucleus speckle.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0036002	pre-mRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000380	alternative mRNA splicing, via spliceosome
GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006376	mRNA splice site selection
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0010837	regulation of keratinocyte proliferation
GO:0031124	mRNA 3'-end processing
GO:0045617	negative regulation of keratinocyte differentiation
GO:0048025	negative regulation of mRNA splicing, via spliceosome
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060548	negative regulation of cell death
GO:0061041	regulation of wound healing