InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SRSF6

Summary

InnateDB Gene

IDBG-75761.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRSF6

Gene Name

serine/arginine-rich splicing factor 6

Synonyms

B52; HEL-S-91; SFRS6; SRP55

Species

Homo sapiens

Ensembl Gene

ENSG00000124193

Encoded Proteins

IDBP-75763

serine/arginine-rich splicing factor 6

IDBP-600062

serine/arginine-rich splicing factor 6

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is involved in mRNA splicing and may play a role in the determination of alternative splicing. The encoded nuclear protein belongs to the splicing factor SR family and has been shown to bind with and modulate another member of the family, SFRS12. Alternative splicing results in multiple transcript variants. In addition, two pseudogenes, one on chromosome 17 and the other on the X chromosome, have been found for this gene.[provided by RefSeq, Sep 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:43457928-43464247

Strand

Forward strand

Band

q13.11

Transcripts

ENST00000244020	ENSP00000244020
ENST00000483871	ENSP00000433544

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 51 experimentally validated interaction(s) in this database.

Experimentally validated
Total	51 [view]
Protein-Protein	51 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0036002	pre-mRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000380	alternative mRNA splicing, via spliceosome
GO:0000381	regulation of alternative mRNA splicing, via spliceosome
GO:0000398	mRNA splicing, via spliceosome
GO:0006366	transcription from RNA polymerase II promoter
GO:0006369	termination of RNA polymerase II transcription
GO:0006376	mRNA splice site selection
GO:0006406	mRNA export from nucleus
GO:0008380	RNA splicing
GO:0010467	gene expression
GO:0010837	regulation of keratinocyte proliferation
GO:0031124	mRNA 3'-end processing
GO:0045617	negative regulation of keratinocyte differentiation
GO:0048025	negative regulation of mRNA splicing, via spliceosome
GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:0060548	negative regulation of cell death
GO:0061041	regulation of wound healing