InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DRP2

Summary

InnateDB Protein

IDBP-600102.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DRP2

Protein Name

dystrophin related protein 2

Synonyms

DRP-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000441051

InnateDB Gene

IDBG-79514 (DRP2)

Protein Structure

UniProt Annotation

Function

Possibly involved in membrane-cytoskeleton interactions of the central nervous system. {ECO:0000269PubMed:8640231}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000305PubMed:8640231}.

Disease Associations

Tissue Specificity

Brain and spinal cord; very low levels in eye, ovary, epididymis and testis; not in cardiac and skeletal muscle. {ECO:0000269PubMed:8640231}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding

Biological Process

GO:0007417

central nervous system development

Cellular Component

GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000433 Zinc finger, ZZ-type
IPR001202 WW domain
IPR002017 Spectrin repeat
IPR015153 EF-hand domain, type 1
IPR015154 EF-hand domain, type 2
IPR017433 Dystrophin-related protein 2
IPR018159 Spectrin/alpha-actinin

PFAM

PF00569
PF00397
PF00435
PF09068
PF09069

PRINTS

PIRSF

PIRSF038205

SMART

SM00291
SM00456
SM00150

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt