Version 5.4
| Homo sapiens Protein: FCRL3 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Protein | IDBP-600103.3 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | FCRL3 | ||||||||||||||||||
| Protein Name | Fc receptor-like 3 | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Protein | ENSP00000435487 | ||||||||||||||||||
| InnateDB Gene | IDBG-103681 (FCRL3) | ||||||||||||||||||
| Protein Structure |
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| UniProt Annotation | |||||||||||||||||||
| Function | |||||||||||||||||||
| Subcellular Localization | Cell membrane {ECO:0000269PubMed:16849395}; Single-pass type I membrane protein {ECO:0000269PubMed:16849395}. | ||||||||||||||||||
| Disease Associations | Rheumatoid arthritis (RA) [MIM:180300]: An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. {ECO:0000269PubMed:15838509, ECO:0000269PubMed:16176992, ECO:0000269PubMed:16476711, ECO:0000269PubMed:16859508, ECO:0000269PubMed:17133579, ECO:0000269PubMed:17179172, ECO:0000269PubMed:17763442}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.Note=Genetic variation in FCRL3 may influence susceptibility to autoimmune disorders, including Graves disease. Graves disease is an autoimmune disorder associated with overactivity of the thyroid gland and hyperthyroidism. | ||||||||||||||||||
| Tissue Specificity | Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus. Expressed a low levels in naive, germinal center and memory B-cells but also expressed in NK cells (at protein level). {ECO:0000269PubMed:11493702, ECO:0000269PubMed:11929751, ECO:0000269PubMed:12051764, ECO:0000269PubMed:15838509, ECO:0000269PubMed:16849395}. | ||||||||||||||||||
| Comments | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Protein Structure and Domains | |||||||||||||||||||
| PDB ID | |||||||||||||||||||
| InterPro |
IPR003598
Immunoglobulin subtype 2 IPR003599 Immunoglobulin subtype IPR007110 Immunoglobulin-like domain IPR013151 Immunoglobulin |
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| PFAM |
PF00047
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| PRINTS | |||||||||||||||||||
| PIRSF | |||||||||||||||||||
| SMART |
SM00408
SM00409 |
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| TIGRFAMs | |||||||||||||||||||
| Post-translational Modifications | |||||||||||||||||||
| Modification | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q96P31 | ||||||||||||||||||
| PhosphoSite | PhosphoSite-Q96P31 | ||||||||||||||||||
| TrEMBL | R4GNJ6 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 115352 | ||||||||||||||||||
| UniGene | Hs.733831 | ||||||||||||||||||
| RefSeq | |||||||||||||||||||
| HUGO | HGNC:18506 | ||||||||||||||||||
| OMIM | 606510 | ||||||||||||||||||
| CCDS | |||||||||||||||||||
| HPRD | 07352 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AF416901 AF416902 AF416903 AF416904 AF416905 AK098122 AL356276 AY043466 BC028933 CH471121 EF064732 | ||||||||||||||||||
| GenPept | AAH28933 AAK91779 AAL13290 AAL13291 AAL13292 AAL13293 AAL13294 ABK41915 CAH73055 CAH73056 CAH73058 EAW52872 EAW52876 EAW52877 | ||||||||||||||||||