InnateDB Protein
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IDBP-600158.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PRKAG3
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Protein Name
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protein kinase, AMP-activated, gamma 3 non-catalytic subunit
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000436068
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InnateDB Gene
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IDBG-81160 (PRKAG3)
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Protein Structure
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Function |
AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. {ECO:0000269PubMed:14722619}.
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Subcellular Localization |
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Disease Associations |
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Tissue Specificity |
Skeletal muscle, with weak expression in heart and pancreas.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR000644
CBS domain
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PFAM |
PF00571
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PRINTS |
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PIRSF |
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SMART |
SM00116
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TIGRFAMs |
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Modification |
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SwissProt |
Q9UGI9
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PhosphoSite |
PhosphoSite-Q9UGI9
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TrEMBL |
B4DT70
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UniProt Splice Variant |
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Entrez Gene |
53632
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UniGene |
Hs.591634
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RefSeq |
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HUGO |
HGNC:9387
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OMIM |
604976
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CCDS |
CCDS2424
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HPRD |
16085
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IMGT |
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EMBL |
AC009974
AF214519
AJ249977
AK300078
BC098102
BC098255
BC098277
BC098306
CH471063
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GenPept |
AAF73987
AAH98102
AAH98255
AAH98277
AAH98306
BAG61882
CAB65117
EAW70656
EAW70657
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