InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SSH3

Summary

InnateDB Protein

IDBP-60017.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SSH3

Protein Name

slingshot homolog 3 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000365948

InnateDB Gene

IDBG-60011 (SSH3)

Protein Structure

UniProt Annotation

Function

Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003779	actin binding
GO:0004725	protein tyrosine phosphatase activity
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0006470	protein dephosphorylation
GO:0008064	regulation of actin polymerization or depolymerization
GO:0010591	regulation of lamellipodium assembly
GO:0016311	dephosphorylation
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0050770	regulation of axonogenesis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton

Protein Structure and Domains

PDB ID

InterPro

IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR014876 DEK, C-terminal
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00102
PF00782
PF08766

PRINTS

PR00700

PIRSF

SMART

SM00194
SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt