Version 5.4
Homo sapiens Gene: SSH3
Summary
InnateDB Gene IDBG-60011.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SSH3
Gene Name slingshot homolog 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000172830
Encoded Proteins
IDBP-60013
slingshot homolog 3 (Drosophila)
IDBP-60015
slingshot homolog 3 (Drosophila)
IDBP-60017
slingshot homolog 3 (Drosophila)
IDBP-591824
slingshot homolog 3 (Drosophila)
IDBP-593918
slingshot homolog 3 (Drosophila)
IDBP-809846
slingshot protein phosphatase 3
IDBP-585385
slingshot homolog 3 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics. ADF/cofilin proteins are inactivated by kinases such as LIM domain kinase-1 (LIMK1; MIM 601329). The SSH family appears to play a role in actin dynamics by reactivating ADF/cofilin proteins in vivo (Niwa et al., 2002 [PubMed 11832213]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:67303448-67312607
Strand Forward strand
Band q13.2
Transcripts
ENST00000308298 ENSP00000310055
ENST00000308127 ENSP00000312081
ENST00000376757 ENSP00000365948
ENST00000532881 ENSP00000431788
ENST00000532600 ENSP00000432974
ENST00000534112
ENST00000532181 ENSP00000480198
ENST00000529224
ENST00000527821 ENSP00000433902
ENST00000531495
ENST00000525913
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003779 actin binding
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
Biological Process
GO:0006470 protein dephosphorylation
GO:0008064 regulation of actin polymerization or depolymerization
GO:0010591 regulation of lamellipodium assembly
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0050770 regulation of axonogenesis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034616
View Gene Order
ENSBTAG00000031590
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PIT5
UniProt Splice Variant
Entrez Gene 54961
UniGene Hs.29173
RefSeq NM_017857
HUGO HGNC:30581
OMIM 606780
CCDS CCDS8157
HPRD 09488
IMGT
EMBL AP001885
GenPept
RNA Seq Atlas 54961

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca