InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HLF

Summary

InnateDB Protein

IDBP-60023.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLF

Protein Name

hepatic leukemia factor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000226067

InnateDB Gene

IDBG-60021 (HLF)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Note=A chromosomal aberration involving HLF is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(17;19)(q22;p13.3) with TCF3.

Tissue Specificity

Highly expressed in liver; lower levels in lung and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003690	double-stranded DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0007275	multicellular organismal development
GO:0035914	skeletal muscle cell differentiation
GO:0048511	rhythmic process