Version 5.4
Homo sapiens Protein: HSD17B6
Summary
InnateDB Protein IDBP-600262.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSD17B6
Protein Name hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse)
Synonyms HSE; RODH; SDR9C6;
Species Homo sapiens
Ensembl Protein ENSP00000452273
InnateDB Gene IDBG-41601 (HSD17B6)
Protein Structure
UniProt Annotation
Function NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha- androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids. {ECO:0000269PubMed:10896656, ECO:0000269PubMed:11360992, ECO:0000269PubMed:11513953}.
Subcellular Localization Microsome membrane {ECO:0000269PubMed:11360992}; Peripheral membrane protein {ECO:0000269PubMed:11360992}; Lumenal side {ECO:0000269PubMed:11360992}. Early endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}; Lumenal side {ECO:0000305}.
Disease Associations
Tissue Specificity Detected in liver and prostate (at protein level). Detected in adult liver, lung, brain, placenta, prostate, adrenal gland, testis, mammary gland, spleen, spinal cord and uterus. Detected in caudate nucleus, and at lower levels in amygdala, corpus callosum, hippocampus, substantia nigra and thalamus. Detected in fetal lung, liver and brain. {ECO:0000269PubMed:10896656, ECO:0000269PubMed:9188497}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004303 estradiol 17-beta-dehydrogenase activity
GO:0004745 retinol dehydrogenase activity
GO:0009055 electron carrier activity
GO:0016491 oxidoreductase activity
GO:0047035 testosterone dehydrogenase (NAD+) activity
Biological Process
GO:0006702 androgen biosynthetic process
GO:0006710 androgen catabolic process
GO:0008152 metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005622 intracellular
GO:0005783 endoplasmic reticulum
GO:0031901 early endosome membrane
Protein Structure and Domains
PDB ID
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
IPR002347 Glucose/ribitol dehydrogenase
PFAM PF00106
PRINTS PR00080
PR00081
PIRSF PIRSF000126
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O14756
PhosphoSite PhosphoSite-O14756
TrEMBL G3V508
UniProt Splice Variant
Entrez Gene 8630
UniGene Hs.736027
RefSeq
HUGO HGNC:23316
OMIM 606623
CCDS CCDS8925
HPRD 09431
IMGT
EMBL AC117378 AC121758 AF016509 AF223225 BC020710 CH471054 U89281
GenPept AAB67236 AAB88252 AAF81017 AAH20710 EAW96963 EAW96964 EAW96965 EAW96966

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca