InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: LIG1

Summary

InnateDB Protein

IDBP-60040.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIG1

Protein Name

ligase I, DNA, ATP-dependent

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000263274

InnateDB Gene

IDBG-60038 (LIG1)

Protein Structure

UniProt Annotation

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	10 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0000724	double-strand break repair via homologous recombination
GO:0006259	DNA metabolic process
GO:0006260	DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006273	lagging strand elongation
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0009653	anatomical structure morphogenesis
GO:0032201	telomere maintenance via semi-conservative replication
GO:0042542	response to hydrogen peroxide
GO:0051103	DNA ligation involved in DNA repair
GO:0051301	cell division
GO:0071897	DNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

InterPro

IPR000977 DNA ligase, ATP-dependent
IPR012308 DNA ligase, ATP-dependent, N-terminal
IPR012309 DNA ligase, ATP-dependent, C-terminal
IPR012310 DNA ligase, ATP-dependent, central
IPR012340 Nucleic acid-binding, OB-fold

PFAM

PF04675
PF04679
PF01068

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P18858

PhosphoSite