InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LIG1

Summary

InnateDB Gene

IDBG-60038.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LIG1

Gene Name

ligase I, DNA, ATP-dependent

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000105486

Encoded Proteins

IDBP-60040

ligase I, DNA, ATP-dependent

IDBP-600515

ligase I, DNA, ATP-dependent

IDBP-587300

ligase I, DNA, ATP-dependent

IDBP-600070

ligase I, DNA, ATP-dependent

IDBP-762431

IDBP-762498

IDBP-766254

IDBP-762830

IDBP-765222

IDBP-765946

IDBP-807395

ligase I, DNA, ATP-dependent

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

LIG1 encodes DNA ligase I, with functions in DNA replication and the base excision repair process. Mutations in LIG1 that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. [provided by RefSeq, Jul 2008]
This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:48115445-48170603

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000263274	ENSP00000263274
ENST00000427526	ENSP00000442841
ENST00000536218	ENSP00000441531
ENST00000542460	ENSP00000445928
ENST00000595758
ENST00000599165
ENST00000599322
ENST00000596549	ENSP00000471861
ENST00000596672	ENSP00000472331
ENST00000601091	ENSP00000471836
ENST00000593425	ENSP00000469638
ENST00000596457
ENST00000594759	ENSP00000471380
ENST00000598938	ENSP00000472085
ENST00000597901
ENST00000596332
ENST00000596104
ENST00000597146
ENST00000600055
ENST00000594067
ENST00000613670	ENSP00000483027

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.

Experimentally validated
Total	13 [view]
Protein-Protein	10 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003909	DNA ligase activity
GO:0003910	DNA ligase (ATP) activity
GO:0005524	ATP binding
GO:0046872	metal ion binding

Biological Process

GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0000724	double-strand break repair via homologous recombination
GO:0006259	DNA metabolic process
GO:0006260	DNA replication
GO:0006266	DNA ligation
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006273	lagging strand elongation
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0006302	double-strand break repair
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0006310	DNA recombination
GO:0009653	anatomical structure morphogenesis
GO:0032201	telomere maintenance via semi-conservative replication
GO:0042542	response to hydrogen peroxide
GO:0051103	DNA ligation involved in DNA repair
GO:0051301	cell division
GO:0071897	DNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005694	chromosome
GO:0005739	mitochondrion
GO:0005794	Golgi apparatus
GO:0043231	intracellular membrane-bounded organelle