InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: HSF1

Summary

InnateDB Protein

IDBP-600409.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HSF1

Protein Name

heat shock transcription factor 1

Synonyms

HSTF1;

Species

Homo sapiens

Ensembl Protein

ENSP00000431512

InnateDB Gene

IDBG-40498 (HSF1)

Protein Structure

UniProt Annotation

Function

DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. In higher eukaryotes, HSF is unable to bind to the HSE unless the cells are heat shocked. {ECO:0000269PubMed:11447121, ECO:0000269PubMed:11583998, ECO:0000269PubMed:12659875, ECO:0000269PubMed:12665592, ECO:0000269PubMed:16278218, ECO:0000269PubMed:8946918, ECO:0000269PubMed:9121459, ECO:0000269PubMed:9535852}.

Subcellular Localization

Cytoplasm. Nucleus. Note=Cytoplasmic during normal growth. On activation, translocates to nuclear stress granules. Colocalizes with SUMO1 in nuclear stress granules.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 122 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	122 [view]
Protein-Protein	115 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001701	in utero embryonic development
GO:0001892	embryonic placenta development
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006952	defense response
GO:0007143	female meiotic division
GO:0007283	spermatogenesis
GO:0008285	negative regulation of cell proliferation
GO:0009408	response to heat
GO:0032496	response to lipopolysaccharide
GO:0032720	negative regulation of tumor necrosis factor production
GO:0034605	cellular response to heat
GO:0040018	positive regulation of multicellular organism growth
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0060136	embryonic process involved in female pregnancy
GO:0090231	regulation of spindle checkpoint