InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GRM4

Summary

InnateDB Protein

IDBP-600625.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GRM4

Protein Name

glutamate receptor, metabotropic 4

Synonyms

GPRC1D; mGlu4; MGLUR4;

Species

Homo sapiens

Ensembl Protein

ENSP00000440556

InnateDB Gene

IDBG-83286 (GRM4)

Protein Structure

UniProt Annotation

Function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. {ECO:0000269PubMed:7617140, ECO:0000269PubMed:8738157, ECO:0000269PubMed:9473604}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:7617140, ECO:0000269PubMed:8738157}; Multi-pass membrane protein {ECO:0000269PubMed:7617140, ECO:0000269PubMed:8738157}.

Disease Associations

Tissue Specificity

Strongly expressed in the cerebellum. Expressed at low levels in hippocampus, hypothalamus and thalamus. No expression detected in liver. {ECO:0000269PubMed:7617140, ECO:0000269PubMed:8738157}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001642	group III metabotropic glutamate receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0005516	calmodulin binding
GO:0008066	glutamate receptor activity
GO:0048306	calcium-dependent protein binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007196	adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0007612	learning
GO:0043410	positive regulation of MAPK cascade
GO:0043523	regulation of neuron apoptotic process
GO:0051966	regulation of synaptic transmission, glutamatergic

Cellular Component

GO:0005622	intracellular
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0031410	cytoplasmic vesicle
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043195	terminal bouton
GO:0043198	dendritic shaft
GO:0048787	presynaptic active zone membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000162 GPCR, family 3, metabotropic glutamate receptor
IPR000337 GPCR, family 3
IPR001786 GPCR, family 3, metabotropic glutamate receptor 4
IPR001828 Extracellular ligand-binding receptor
IPR011500 GPCR, family 3, nine cysteines domain
IPR017978 GPCR, family 3, C-terminal
IPR028082 Periplasmic binding protein-like I

PFAM

PF01094
PF07562
PF00003

PRINTS

PR00593
PR00248
PR01054

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q14833