InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SSH1

Summary

InnateDB Protein

IDBP-600670.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SSH1

Protein Name

slingshot homolog 1 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000448824

InnateDB Gene

IDBG-55527 (SSH1)

Protein Structure

UniProt Annotation

Function

Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein. {ECO:0000269PubMed:11832213, ECO:0000269PubMed:12684437, ECO:0000269PubMed:12807904, ECO:0000269PubMed:14531860, ECO:0000269PubMed:14645219, ECO:0000269PubMed:15056216, ECO:0000269PubMed:15159416, ECO:0000269PubMed:15660133, ECO:0000269PubMed:15671020, ECO:0000269PubMed:16230460}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Cleavage furrow. Midbody. Note=Also recruited to actin rich membrane protrusions such as lamellipodia, which may allow local control of actin dynamics at sites of cell locomotion. Also localized to the cleavage furrow and the midbody during cytokinesis.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.

Experimentally validated
Total	19 [view]
Protein-Protein	19 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003779	actin binding
GO:0004721	phosphoprotein phosphatase activity
GO:0004725	protein tyrosine phosphatase activity
GO:0005515	protein binding
GO:0008138	protein tyrosine/serine/threonine phosphatase activity
GO:0016791	phosphatase activity

Biological Process

GO:0000902	cell morphogenesis
GO:0006470	protein dephosphorylation
GO:0008064	regulation of actin polymerization or depolymerization
GO:0010591	regulation of lamellipodium assembly
GO:0016311	dephosphorylation
GO:0030036	actin cytoskeleton organization
GO:0032268	regulation of cellular protein metabolic process
GO:0035335	peptidyl-tyrosine dephosphorylation
GO:0050770	regulation of axonogenesis
GO:0071318	cellular response to ATP

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0030027	lamellipodium
GO:0030496	midbody
GO:0032154	cleavage furrow

Protein Structure and Domains

PDB ID

InterPro

IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR014876 DEK, C-terminal
IPR020422 Dual specificity phosphatase, subgroup, catalytic domain
IPR029021 Protein-tyrosine phosphatase-like

PFAM

PF00782
PF08766

PRINTS

PIRSF

SMART

SM00195

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8WYL5