InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TMF1

Summary

InnateDB Protein

IDBP-600836.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TMF1

Protein Name

TATA element modulatory factor 1

Synonyms

ARA160; TMF;

Species

Homo sapiens

Ensembl Protein

ENSP00000438706

InnateDB Gene

IDBG-43864 (TMF1)

Protein Structure

UniProt Annotation

Function

Potential coactivator of the androgen receptor. Mediates STAT3 degradation. May play critical roles in two RAB6-dependent retrograde transport processes: one from endosomes to the Golgi and the other from the Golgi to the ER. This protein binds the HIV-1 TATA element and inhibits transcriptional activation by the TATA-binding protein (TBP). {ECO:0000269PubMed:10428808, ECO:0000269PubMed:1409643, ECO:0000269PubMed:15467733, ECO:0000269PubMed:17698061}.

Subcellular Localization

Cytoplasm. Nucleus. Golgi apparatus membrane. Note=Concentrated at the budding structures localized at the tips of cisternae.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	11 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003712	transcription cofactor activity
GO:0005515	protein binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0061136	regulation of proteasomal protein catabolic process