Version 5.4
Homo sapiens Protein: LCOR
Summary
InnateDB Protein IDBP-601116.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LCOR
Protein Name ligand dependent nuclear receptor corepressor
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000443431
InnateDB Gene IDBG-84045 (LCOR)
Protein Structure
UniProt Annotation
Function May act as transcription activator that binds DNA elements with the sequence 5'-CCCTATCGATCGATCTCTACCT-3' (By similarity). Repressor of ligand-dependent transcription activation by target nuclear receptors. Repressor of ligand- dependent transcription activation by ESR1, ESR2, NR3C1, PGR, RARA, RARB, RARG, RXRA and VDR. {ECO:0000250, ECO:0000269PubMed:12535528}.
Subcellular Localization Nucleus {ECO:0000255PROSITE- ProRule:PRU00320, ECO:0000269PubMed:12535528}.
Disease Associations
Tissue Specificity Ubiquitous. {ECO:0000269PubMed:12535528}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR007889 DNA binding HTH domain, Psq-type
IPR009057 Homeodomain-like
PFAM PF04218
PF05225
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96JN0
PhosphoSite PhosphoSite-Q96JN0
TrEMBL
UniProt Splice Variant
Entrez Gene 84458
UniGene Hs.743465
RefSeq NP_001164237
HUGO HGNC:29503
OMIM 607698
CCDS CCDS53561
HPRD 07609
IMGT
EMBL AB058698 AL442123 AL832044 AL832106 AL834245 BC053359 CH471066
GenPept AAH53359 BAB47424 CAD38921 CAD91159 CAD91160 CAH70915 EAW49963 EAW49965 EAW49966

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca