Version 5.4
Homo sapiens Gene: LCOR
Summary
InnateDB Gene IDBG-84045.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LCOR
Gene Name ligand dependent nuclear receptor corepressor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000196233
Encoded Proteins
IDBP-84047
ligand dependent nuclear receptor corepressor
IDBP-84049
ligand dependent nuclear receptor corepressor
IDBP-84051
ligand dependent nuclear receptor corepressor
IDBP-601116
ligand dependent nuclear receptor corepressor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:96832260-96981043
Strand Forward strand
Band q24.1
Transcripts
ENST00000371103 ENSP00000360144
ENST00000371097 ENSP00000360138
ENST00000356016 ENSP00000348298
ENST00000493486
ENST00000469510
ENST00000498444
ENST00000463415
ENST00000540664 ENSP00000443431
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025019
View Gene Order
ENSBTAG00000004029
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
era_genomic_pathway
Validated nuclear estrogen receptor alpha network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.644719 Hs.743465
RefSeq NM_001170765 NM_001170766 NM_032440
HUGO
OMIM
CCDS CCDS53561 CCDS7451
HPRD 07609
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca