InnateDB Protein
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IDBP-601447.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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POLR2M
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Protein Name
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glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000432615
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InnateDB Gene
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IDBG-545520 (POLR2M)
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Protein Structure
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Function |
Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. {ECO:0000269PubMed:16769904}.
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Subcellular Localization |
Isoform 1: Nucleus {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Detected in adult an fetal brain. Detected in heart, kidney, skeletal muscle, small intestine, lung, prostate and testis. {ECO:0000269PubMed:15233991}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
21
[view]
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Protein-Protein |
21
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0003899
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DNA-directed RNA polymerase activity
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P0CAP2
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PhosphoSite |
PhosphoSite-P0CAP2
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TrEMBL |
E9PP13
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UniProt Splice Variant |
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Entrez Gene |
81488
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UniGene |
Hs.702937
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RefSeq |
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HUGO |
HGNC:14862
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OMIM |
606485
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CCDS |
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HPRD |
07575
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IMGT |
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EMBL |
AC025271
AC090651
AF326773
AK074767
AK074955
AK128618
AL050091
AY207007
AY353061
BC001510
CH471082
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GenPept |
AAH01510
AAK92284
AAO39707
AAQ76837
BAC11193
BAC11313
BAC87533
CAB43263
EAW77525
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