Version 5.4
Homo sapiens Protein: PLSCR2
Summary
InnateDB Protein IDBP-60153.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PLSCR2
Protein Name phospholipid scramblase 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000338707
InnateDB Gene IDBG-60151 (PLSCR2)
Protein Structure
UniProt Annotation
Function May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. May play a central role in the initiation of fibrin clot formation, in the activation of mast cells and in the recognition of apoptotic and injured cells by the reticuloendothelial system.Isoform 1 has no prospholipid scramblase activity, due to the lack of a N-terminal proline-rich domain.
Subcellular Localization Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.Isoform 1: Nucleus {ECO:0000269PubMed:24648509}.
Disease Associations
Tissue Specificity Expression of isoform 1 seems restricted to testis. {ECO:0000269PubMed:10930526}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0017128 phospholipid scramblase activity
Biological Process
GO:0017121 phospholipid scrambling
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR005552 Scramblase
IPR025659 Tubby C-terminal-like domain
PFAM PF03803
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9NRY7
PhosphoSite PhosphoSite-Q9NRY7
TrEMBL C9J636
UniProt Splice Variant
Entrez Gene 57047
UniGene Hs.177968
RefSeq NP_065092
HUGO HGNC:16494
OMIM 607610
CCDS CCDS3134
HPRD 09621
IMGT
EMBL AC069528 AF159441 AK301909 BC055415 BC069785 BC120969 BC141969
GenPept AAF91082 AAH55415 AAH69785 AAI20970 AAI41970 BAG63335

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca