InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC16A1

Summary

InnateDB Protein

IDBP-601543.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC16A1

Protein Name

solute carrier family 16, member 1 (monocarboxylic acid transporter 1)

Synonyms

HHF7; MCT; MCT1;

Species

Homo sapiens

Ensembl Protein

ENSP00000441065

InnateDB Gene

IDBG-101192 (SLC16A1)

Protein Structure

UniProt Annotation

Function

Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. {ECO:0000269PubMed:17701893}.

Subcellular Localization

Cell membrane {ECO:0000269PubMed:15505343, ECO:0000269PubMed:17127621, ECO:0000269PubMed:24390345}; Multi- pass membrane protein {ECO:0000269PubMed:15505343, ECO:0000269PubMed:17127621, ECO:0000269PubMed:24390345}.

Disease Associations

Symptomatic deficiency in lactate transport (SDLT) [MIM:245340]: Deficiency of lactate transporter may result in an acidic intracellular environment created by muscle activity with consequent degeneration of muscle and release of myoglobin and creatine kinase. This defect might compromise extreme performance in otherwise healthy individuals. {ECO:0000269PubMed:10590411}. Note=The disease is caused by mutations affecting the gene represented in this entry.Familial hyperinsulinemic hypoglycemia 7 (HHF7) [MIM:610021]: Dominantly inherited hypoglycemic disorder characterized by inappropriate insulin secretion during anaerobic exercise or on pyruvate load. {ECO:0000269PubMed:17701893}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Detected in heart and in blood lymphocytes and monocytes (at protein level). Widely expressed. {ECO:0000269PubMed:15505343}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008028	monocarboxylic acid transmembrane transporter activity
GO:0015130	mevalonate transmembrane transporter activity
GO:0015293	symporter activity
GO:0015355	secondary active monocarboxylate transmembrane transporter activity
GO:0042803	protein homodimerization activity
GO:0097159	organic cyclic compound binding

Biological Process

GO:0006090	pyruvate metabolic process
GO:0006629	lipid metabolic process
GO:0007596	blood coagulation
GO:0015711	organic anion transport
GO:0015718	monocarboxylic acid transport
GO:0015728	mevalonate transport
GO:0032094	response to food
GO:0035873	lactate transmembrane transport
GO:0035879	plasma membrane lactate transport
GO:0042593	glucose homeostasis
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0050900	leukocyte migration
GO:0051297	centrosome organization
GO:0051780	behavioral response to nutrient
GO:0055085	transmembrane transport
GO:0071407	cellular response to organic cyclic compound

Cellular Component

GO:0005739	mitochondrion
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR004743 Monocarboxylate transporter
IPR011701 Major facilitator superfamily
IPR016196 Major facilitator superfamily domain, general substrate transporter
IPR020846 Major facilitator superfamily domain

PFAM

PF07690

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P53985

PhosphoSite