Version 5.4
Homo sapiens Protein: PSPC1
Summary
InnateDB Protein IDBP-601703.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSPC1
Protein Name paraspeckle component 1
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000436038
InnateDB Gene IDBG-12561 (PSPC1)
Protein Structure
UniProt Annotation
Function Regulates, cooperatively with NONO and SFPQ, androgen receptor-mediated gene transcription activity in Sertoli cell line (By similarity). Binds to poly(A), poly(G) and poly(U) RNA homopolymers. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Together with NONO, required for the formation of nuclear paraspeckles. {ECO:0000250, ECO:0000269PubMed:22416126}.
Subcellular Localization Nucleus, nucleolus. Nucleus matrix {ECO:0000250}. Cytoplasm {ECO:0000250}. Nucleus speckle. Note=In punctate subnuclear structures often located adjacent to splicing speckles, called paraspeckles. Colocalizes with NONO and SFPQ in paraspeckles and perinucleolar caps in an RNA-dependent manner. May cycles between paraspeckles and nucleolus. In telophase, when daughter nuclei form, localizes to perinucleolar caps.
Disease Associations
Tissue Specificity Expressed in pancreas, kidney, skeletal muscle, liver, lung, placenta, brain and heart. {ECO:0000269PubMed:11790299}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0001047 core promoter binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0042752 regulation of circadian rhythm
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016363 nuclear matrix
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR012975 NOPS
PFAM PF00076
PF08075
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8WXF1
PhosphoSite PhosphoSite-Q8WXF1
TrEMBL X6RDA4
UniProt Splice Variant
Entrez Gene 55269
UniGene Hs.732043
RefSeq
HUGO HGNC:20320
OMIM 612408
CCDS
HPRD 10172
IMGT
EMBL AF448795 AF449627 AK001817 AL354808 AL834505 BC014184 CH471075 CR457272
GenPept AAH14184 AAL59601 AAL59602 BAA91924 CAD39162 CAG33553 CAI41004 CAI41005 EAX08232 EAX08233 EAX08234

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca