InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PSPC1

Summary

InnateDB Gene

IDBG-12561.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PSPC1

Gene Name

paraspeckle component 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000121390

Encoded Proteins

IDBP-12567

paraspeckle component 1

IDBP-361075

paraspeckle component 1

IDBP-601703

paraspeckle component 1

IDBP-585106

paraspeckle component 1

IDBP-811952

paraspeckle component 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a nucleolar protein that localizes to punctate subnuclear structures that occur close to splicing speckles, known as paraspeckles. These paraspeckles are composed of RNA-protein structures that include a non-coding RNA, NEAT1/Men epsilon/beta, and the Drosophila Behavior Human Splicing family of proteins, which include the product of this gene and the P54NRB/NONO and PSF/SFPQ proteins. Paraspeckles may function in the control of gene expression via an RNA nuclear retention mechanism. The protein encoded by this gene is found in paraspeckles in transcriptionally active cells, but it localizes to unique cap structures at the nucleolar periphery when RNA polymerase II transcription is inhibited, or during telophase. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene, which is also located on chromosome 13, has been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:19674752-19783019

Strand

Reverse strand

Band

q12.11

Transcripts

ENST00000338910	ENSP00000343966
ENST00000427943	ENSP00000393069
ENST00000471658	ENSP00000436038
ENST00000497722
ENST00000492741	ENSP00000435921
ENST00000619300	ENSP00000481916

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001047	core promoter binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0042752	regulation of circadian rhythm
GO:0045892	negative regulation of transcription, DNA-templated

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016363	nuclear matrix
GO:0016607	nuclear speck
GO:0042382	paraspeckles

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000021938

View Gene Order

ENSBTAG00000003934

Not yet available

Pathways

NETPATH

NetPath_24

TSLP pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.213198 Hs.610343 Hs.629011 Hs.720915 Hs.732043

RefSeq

NM_001042414 XM_006719844

HUGO

OMIM

CCDS

CCDS41870

HPRD

10172

IMGT

EMBL

GenPept

RNA Seq Atlas