Version 5.4
Homo sapiens Protein: FAM109A
Summary
InnateDB Protein IDBP-601766.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAM109A
Protein Name family with sequence similarity 109, member A
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000449994
InnateDB Gene IDBG-57442 (FAM109A)
Protein Structure
UniProt Annotation
Function Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane. {ECO:0000269PubMed:21233288}.
Subcellular Localization Early endosome. Recycling endosome. Golgi apparatus, trans-Golgi network. Cytoplasmic vesicle, clathrin- coated vesicle. Note=Interaction with OCRL may be crucial for targeting to endosome and to the trans-Golgi network. Also found on macropinosomes. Not detected in late endosomes, nor in lysosomes.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001881 receptor recycling
GO:0007032 endosome organization
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0005769 early endosome
GO:0005802 trans-Golgi network
GO:0030136 clathrin-coated vesicle
GO:0055037 recycling endosome
Protein Structure and Domains
PDB ID
InterPro IPR001849 Pleckstrin homology domain
PFAM PF00169
PRINTS
PIRSF
SMART SM00233
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8N4B1
PhosphoSite PhosphoSite-Q8N4B1
TrEMBL F8W0V2
UniProt Splice Variant
Entrez Gene 144717
UniGene Hs.173088
RefSeq XP_006719320
HUGO HGNC:26509
OMIM 614239
CCDS CCDS9152
HPRD 08127
IMGT
EMBL AC005805 AK056918 AK299344 BC014091 BC034809 CX758147
GenPept AAH14091 AAH34809 BAB71310 BAG61345

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca