InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: DCTN3

Summary

InnateDB Protein

IDBP-60177.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DCTN3

Protein Name

dynactin 3 (p22)

Synonyms

DCTN-22; DCTN22;

Species

Homo sapiens

Ensembl Protein

ENSP00000259632

InnateDB Gene

IDBG-60175 (DCTN3)

Protein Structure

UniProt Annotation

Function

Together with dynein may be involved in spindle assembly and cytokinesis. {ECO:0000269PubMed:9722614}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:9722614}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:9722614}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:9722614}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:9722614}. Cleavage furrow {ECO:0000269PubMed:9722614}. Midbody {ECO:0000269PubMed:9722614}. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain. {ECO:0000269PubMed:9722614}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005198	structural molecule activity
GO:0005515	protein binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0000910	cytokinesis
GO:0007017	microtubule-based process
GO:0007067	mitotic nuclear division
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005813	centrosome
GO:0005819	spindle
GO:0005829	cytosol
GO:0005869	dynactin complex
GO:0005875	microtubule associated complex
GO:0030496	midbody
GO:0032154	cleavage furrow
GO:0048471	perinuclear region of cytoplasm