Version 5.4
Homo sapiens Protein: SRSF5
Summary
InnateDB Protein IDBP-601800.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRSF5
Protein Name serine/arginine-rich splicing factor 5
Synonyms HRS; SFRS5; SRP40;
Species Homo sapiens
Ensembl Protein ENSP00000451088
InnateDB Gene IDBG-10497 (SRSF5)
Protein Structure
UniProt Annotation
Function Plays a role in constitutive splicing and can modulate the selection of alternative splice sites.
Subcellular Localization Nucleus.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 107 experimentally validated interaction(s) in this database.
Experimentally validated
Total 107 [view]
Protein-Protein 104 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0000398 mRNA splicing, via spliceosome
GO:0006366 transcription from RNA polymerase II promoter
GO:0006369 termination of RNA polymerase II transcription
GO:0006376 mRNA splice site selection
GO:0006397 mRNA processing
GO:0006406 mRNA export from nucleus
GO:0008380 RNA splicing
GO:0010467 gene expression
GO:0031124 mRNA 3'-end processing
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
PFAM PF00076
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q13243
PhosphoSite PhosphoSite-Q13243
TrEMBL Q86U32
UniProt Splice Variant
Entrez Gene 6430
UniGene Hs.734522
RefSeq NP_008856
HUGO HGNC:10787
OMIM 600914
CCDS CCDS32109
HPRD
IMGT
EMBL AB451250 AF020307 AK311805 AL157789 AL355837 BC018823 BC040209 BT007089 BX247988 BX640605 CH471061 CR542167 CR542182 U30826 U30827 U30884
GenPept AAA93070 AAA93074 AAB60405 AAC39543 AAH18823 AAH40209 AAP35752 BAG34748 BAG70064 CAD62322 CAE45711 CAG46964 CAG46979 EAW81002 EAW81004 EAW81005 EAW81006 EAW81007 EAW81009

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca