InnateDB Protein
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IDBP-60181.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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DCTN3
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Protein Name
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dynactin 3 (p22)
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Synonyms
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DCTN-22; DCTN22;
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000343986
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InnateDB Gene
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IDBG-60175 (DCTN3)
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Protein Structure
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Function |
Together with dynein may be involved in spindle assembly and cytokinesis. {ECO:0000269PubMed:9722614}.
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Subcellular Localization |
Cytoplasm {ECO:0000269PubMed:9722614}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269PubMed:9722614}. Chromosome, centromere, kinetochore {ECO:0000269PubMed:9722614}. Cytoplasm, cytoskeleton, spindle {ECO:0000269PubMed:9722614}. Cleavage furrow {ECO:0000269PubMed:9722614}. Midbody {ECO:0000269PubMed:9722614}. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.
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Disease Associations |
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Tissue Specificity |
Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain. {ECO:0000269PubMed:9722614}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
24
[view]
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Protein-Protein |
22
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR009991
Dynactin subunit p22
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PFAM |
PF07426
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O75935
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PhosphoSite |
PhosphoSite-O75935
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
11258
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UniGene |
Hs.737671
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RefSeq |
NP_077324
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HUGO |
HGNC:2713
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OMIM |
607387
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CCDS |
CCDS6561
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HPRD |
06303
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IMGT |
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EMBL |
AF082513
AK314730
AL160270
AL450283
BC000319
BC003004
BC107697
CH471071
CR541889
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GenPept |
AAC61280
AAH00319
AAH03004
AAI07698
BAG37272
CAG46687
CAI13143
CAI13144
CAI13145
CAI14178
CAI14180
CAI14181
CAI14182
EAW58440
EAW58441
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