InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CTSL2

Summary

InnateDB Protein

IDBP-601850.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CTSL2

Protein Name

cathepsin L2

Synonyms

CATL2; CTSL2; CTSU;

Species

Homo sapiens

Ensembl Protein

ENSP00000445052

InnateDB Gene

IDBG-77609 (CTSL2)

Protein Structure

UniProt Annotation

Function

Cysteine protease. May have an important role in corneal physiology. {ECO:0000269PubMed:10029531, ECO:0000269PubMed:9727401}.

Subcellular Localization

Lysosome {ECO:0000305}.

Disease Associations

Tissue Specificity

Predominantly expressed in the thymus and testis. Also expressed in corneal epithelium, and to a lesser extent in conjunctival epithelium and skin. {ECO:0000269PubMed:10029531, ECO:0000269PubMed:9563472, ECO:0000269PubMed:9727401}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004177	aminopeptidase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0005515	protein binding
GO:0008234	cysteine-type peptidase activity
GO:0016807	cysteine-type carboxypeptidase activity
GO:0030984	kininogen binding
GO:0032403	protein complex binding
GO:0042277	peptide binding
GO:0042393	histone binding

Biological Process

GO:0006508	proteolysis
GO:0007154	cell communication
GO:0007283	spermatogenesis
GO:0008584	male gonad development
GO:0009267	cellular response to starvation
GO:0009749	response to glucose
GO:0010259	multicellular organismal aging
GO:0010839	negative regulation of keratinocyte proliferation
GO:0014070	response to organic cyclic compound
GO:0016485	protein processing
GO:0016540	protein autoprocessing
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0021675	nerve development
GO:0022617	extracellular matrix disassembly
GO:0030198	extracellular matrix organization
GO:0031069	hair follicle morphogenesis
GO:0034698	response to gonadotropin
GO:0042637	catagen
GO:0046697	decidualization
GO:0048102	autophagic cell death
GO:0051384	response to glucocorticoid
GO:0060008	Sertoli cell differentiation
GO:2000249	regulation of actin cytoskeleton reorganization

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005764	lysosome
GO:0005773	vacuole
GO:0005902	microvillus
GO:0009897	external side of plasma membrane
GO:0030141	secretory granule
GO:0031410	cytoplasmic vesicle
GO:0043005	neuron projection
GO:0043202	lysosomal lumen
GO:0043204	perikaryon
GO:0045177	apical part of cell
GO:0070062	extracellular vesicular exosome