Version 5.4
Homo sapiens Protein: SART3
Summary
InnateDB Protein IDBP-601861.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SART3
Protein Name squamous cell carcinoma antigen recognized by T cells 3
Synonyms DSAP1; P100; p110; p110(nrb); RP11-13G14; TIP110;
Species Homo sapiens
Ensembl Protein ENSP00000448554
InnateDB Gene IDBG-55333 (SART3)
Protein Structure
UniProt Annotation
Function Regulates Tat transactivation activity through direct interaction. May be a cellular factor for HIV-1 gene expression and viral replication. {ECO:0000269PubMed:11959860}.
Subcellular Localization Cytoplasm. Nucleus speckle. Note=Localized in speckles. Expressed in the nucleus of all of the malignant tumor cell lines tested and the majority of cancer tissues with various histologies, including squamous cell carcinomas (SCC), adenocarcinomas, melanomas and leukemias cells. However, this protein is undetectable in the nucleus of any cell lines of nonmalignant cells or normal tissues, except for the testis. Expressed in the cytoplasm of all the proliferating cells, including normal and malignant cells, but not in normal tissues, except for the testis and the fetal liver.
Disease Associations Disseminated superficial actinic porokeratosis 1 (DSAP1) [MIM:175900]: Autosomal dominant disorder, characterized by multiple superficial keratotic lesions surrounded by a slightly raised keratotic border, developing during the third or fourth decade of life on sun-exposed areas of skin. {ECO:0000269PubMed:15840095}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Tissue Specificity Ubiquitously expressed. {ECO:0000269PubMed:11959860}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
Experimentally validated
Total 93 [view]
Protein-Protein 91 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006396 RNA processing
GO:0010468 regulation of gene expression
Cellular Component
GO:0005737 cytoplasm
GO:0016607 nuclear speck
Protein Structure and Domains
PDB ID
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q15020
PhosphoSite PhosphoSite-Q15020
TrEMBL
UniProt Splice Variant
Entrez Gene 9733
UniGene
RefSeq
HUGO HGNC:16860
OMIM 611684
CCDS
HPRD 11532
IMGT
EMBL AB020880 AF387506 AK290209 BC032601 BC041638 BC093784 BC103706 BC111983 D63879
GenPept AAH32601 AAH41638 AAH93784 AAI03707 AAI11984 AAK69347 BAA09929 BAA78384 BAF82898

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca