InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GABARAPL1

Summary

InnateDB Protein

IDBP-602107.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GABARAPL1

Protein Name

GABA(A) receptor-associated protein like 1

Synonyms

APG8-LIKE; APG8L; ATG8; ATG8B; ATG8L; GEC1;

Species

Homo sapiens

Ensembl Protein

ENSP00000444186

InnateDB Gene

IDBG-18678 (GABARAPL1)

Protein Structure

UniProt Annotation

Function

Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. {ECO:0000269PubMed:16431922, ECO:0000269PubMed:20404487}.

Subcellular Localization

Cytoplasm, cytoskeleton. Cytoplasmic vesicle membrane; Lipid-anchor. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}. Cytoplasmic vesicle, autophagosome.

Disease Associations

Tissue Specificity

Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. In the brain, expression is particularly intense in motoneurons in the embryo and in neurons involved in somatomotor and neuroendocrine functions in the adult, particularly in the substantia nigra pars compacta. {ECO:0000269PubMed:11374880, ECO:0000269PubMed:11414770, ECO:0000269PubMed:23690988}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 92 experimentally validated interaction(s) in this database.

Experimentally validated
Total	92 [view]
Protein-Protein	91 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0048487	beta-tubulin binding
GO:0050811	GABA receptor binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0006914	autophagy

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005776	autophagic vacuole
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005874	microtubule
GO:0030659	cytoplasmic vesicle membrane