InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SMAD5

Summary

InnateDB Protein

IDBP-602303.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMAD5

Protein Name

SMAD family member 5

Synonyms

DWFC; JV5-1; MADH5;

Species

Homo sapiens

Ensembl Protein

ENSP00000441954

InnateDB Gene

IDBG-45903 (SMAD5)

Protein Structure

UniProt Annotation

Function

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).

Subcellular Localization

Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand. Migrates to the nucleus when complexed with SMAD4.

Disease Associations

Tissue Specificity

Ubiquitous.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 93 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.

Experimentally validated
Total	93 [view]
Protein-Protein	93 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	16 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005057	receptor signaling protein activity
GO:0005515	protein binding
GO:0030618	transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
GO:0031625	ubiquitin protein ligase binding
GO:0046872	metal ion binding

Biological Process

GO:0001503	ossification
GO:0001657	ureteric bud development
GO:0001880	Mullerian duct regression
GO:0002051	osteoblast fate commitment
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0007165	signal transduction
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007281	germ cell development
GO:0009880	embryonic pattern specification
GO:0030218	erythrocyte differentiation
GO:0030509	BMP signaling pathway
GO:0035556	intracellular signal transduction
GO:0045669	positive regulation of osteoblast differentiation
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0051216	cartilage development
GO:0060048	cardiac muscle contraction
GO:0060348	bone development
GO:0071407	cellular response to organic cyclic compound
GO:0071773	cellular response to BMP stimulus
GO:1901522	positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016021	integral component of membrane
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR001132 SMAD domain, Dwarfin-type
IPR003619 MAD homology 1, Dwarfin-type
IPR008984 SMAD/FHA domain
IPR013019 MAD homology, MH1
IPR019471 Interferon regulatory factor-3

PFAM

PF03166
PF03165
PF10401

PRINTS

PIRSF

SMART

SM00524
SM00523

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q99717