InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ZNF385A

Summary

InnateDB Protein

IDBP-602377.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ZNF385A

Protein Name

zinc finger protein 385A

Synonyms

HZF; RZF; ZFP385; ZNF385;

Species

Homo sapiens

Ensembl Protein

ENSP00000447162

InnateDB Gene

IDBG-37861 (ZNF385A)

Protein Structure

UniProt Annotation

Function

RNA-binding protein that affects the localization and the translation of a subset of mRNA. May play a role in adipogenesis through binding to the 3'-UTR of CEBPA mRNA and regulation of its translation. Targets ITPR1 mRNA to dendrites in Purkinje cells, and may regulate its activity-dependent translation. With ELAVL1, binds the 3'-UTR of p53/TP53 mRNAs to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti- proliferative activity. May also bind CCNB1 mRNA. Alternatively, may also regulate p53/TP53 activity through direct protein-protein interaction. Interacts with p53/TP53 and promotes cell-cycle arrest over apoptosis enhancing preferentially the DNA binding and transactivation of p53/TP53 on cell-cycle arrest target genes over proapoptotic target genes. May also regulate the ubiquitination and stability of CDKN1A promoting DNA damage-induced cell cycle arrest. Also plays a role in megakaryocytes differentiation. {ECO:0000269PubMed:17719541}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:15527981}. Nucleus, nucleolus {ECO:0000269PubMed:15527981}. Cell projection, dendrite {ECO:0000250}. Note=Detected in dendrites of Purkinje cells and hippocampal neurons. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed predominantly in the retina. {ECO:0000269PubMed:15527981}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002039	p53 binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0008270	zinc ion binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006915	apoptotic process
GO:0006974	cellular response to DNA damage stimulus
GO:0010609	mRNA localization resulting in posttranscriptional regulation of gene expression
GO:0035855	megakaryocyte development
GO:0045600	positive regulation of fat cell differentiation
GO:1902164	positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:1902166	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:2000765	regulation of cytoplasmic translation