InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SLC24A4

Summary

InnateDB Protein

IDBP-602508.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC24A4

Protein Name

solute carrier family 24 (sodium/potassium/calcium exchanger), member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000433302

InnateDB Gene

IDBG-16940 (SLC24A4)

Protein Structure

UniProt Annotation

Function

Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Note=SLC24A4 mutations may be a cause of autosomal recessive hypomineralized amelogenesis imperfecta (AI), a defect of enamel formation characterized by variable degrees of incomplete mineralization of the enamel matrix, typically with a near-normal enamel matrix volume prior to posteruptive changes and premature failure.

Tissue Specificity

Expressed abundantly in all regions of the brain, aorta, lung and thymus. Expressed at lower levels in the stomach and intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015293	symporter activity

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0007608	sensory perception of smell
GO:0050896	response to stimulus
GO:0055085	transmembrane transport
GO:0097186	amelogenesis