Version 5.4
Homo sapiens Protein: YAF2
Summary
InnateDB Protein IDBP-602518.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YAF2
Protein Name YY1 associated factor 2
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000439256
InnateDB Gene IDBG-27660 (YAF2)
Protein Structure
UniProt Annotation
Function Binds to MYC and inhibits MYC-mediated transactivation. Also binds to MYCN and enhances MYCN-dependent transcriptional activation. Increases calpain 2-mediated proteolysis of YY1 in vitro. Component of the E2F6.com-1 complex, a repressive complex that methylates 'Lys-9' of histone H3, suggesting that it is involved in chromatin-remodeling. {ECO:0000269PubMed:11593398, ECO:0000269PubMed:12706874, ECO:0000269PubMed:9016636}.
Subcellular Localization Nucleus {ECO:0000269PubMed:11593398}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001876 Zinc finger, RanBP2-type
PFAM PF00641
PRINTS
PIRSF
SMART SM00547
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8IY57
PhosphoSite PhosphoSite-Q8IY57
TrEMBL F8VZR2
UniProt Splice Variant
Entrez Gene 10138
UniGene Hs.708084
RefSeq NP_005739
HUGO HGNC:17363
OMIM 607534
CCDS CCDS31775
HPRD 09606
IMGT
EMBL AC020629 AK127531 AK291355 AK294260 BC037777 CH471111 U72209
GenPept AAC51116 AAH37777 BAF84044 BAG57554 EAW57839

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca