Version 5.4
Homo sapiens Gene: YAF2
Summary
InnateDB Gene IDBG-27660.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol YAF2
Gene Name YY1 associated factor 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000015153
Encoded Proteins
IDBP-27662
YY1 associated factor 2
IDBP-27664
YY1 associated factor 2
IDBP-602518
YY1 associated factor 2
IDBP-595241
YY1 associated factor 2
IDBP-589635
YY1 associated factor 2
IDBP-598830
YY1 associated factor 2
IDBP-603460
YY1 associated factor 2
IDBP-599349
YY1 associated factor 2
IDBP-587191
YY1 associated factor 2
IDBP-585869
YY1 associated factor 2
IDBP-596176
YY1 associated factor 2
IDBP-598679
YY1 associated factor 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene interacts with YY1, a zinc finger protein involved in negative regulation of muscle-restricted genes. This gene product itself contains a single N-terminal C2-X10-C2 zinc finger, and in contrast to YY1, is up-regulated during myogenic differentiation. It also facilitates proteolytic cleavage of YY1 by the calcium- activated protease, m-calpain, suggesting a mechanism by which this protein antagonizes the negative effect of YY1. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:42157104-42238349
Strand Reverse strand
Band q12
Transcripts
ENST00000327791 ENSP00000328004
ENST00000380790 ENSP00000370167
ENST00000534854 ENSP00000439256
ENST00000550315
ENST00000552109 ENSP00000448533
ENST00000547622
ENST00000547351 ENSP00000450394
ENST00000551268 ENSP00000448291
ENST00000551528
ENST00000548661 ENSP00000447217
ENST00000546972
ENST00000546726 ENSP00000447863
ENST00000547724
ENST00000552928 ENSP00000450097
ENST00000548917 ENSP00000447686
ENST00000547254 ENSP00000448312
ENST00000541702
ENST00000546782
ENST00000555248 ENSP00000451626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 34 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003713 transcription coactivator activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022634
View Gene Order
ENSBTAG00000015025
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.617142 Hs.649195 Hs.708084
RefSeq NM_001190977 NM_001190979 NM_001190980 NM_005748 XM_006719183 XM_006719184 XM_006719185
HUGO
OMIM
CCDS CCDS31775 CCDS53778 CCDS53779 CCDS53780
HPRD 09606
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca