Homo sapiens Protein: GPRC6A | |||||
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Summary | |||||
InnateDB Protein | IDBP-602584.3 | ||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
Gene Symbol | GPRC6A | ||||
Protein Name | G protein-coupled receptor, family C, group 6, member A | ||||
Synonyms | |||||
Species | Homo sapiens | ||||
Ensembl Protein | ENSP00000433465 | ||||
InnateDB Gene | IDBG-95756 (GPRC6A) | ||||
Protein Structure | |||||
UniProt Annotation | |||||
Function | Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids. {ECO:0000269PubMed:15576628, ECO:0000269PubMed:20947496}. | ||||
Subcellular Localization | Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. | ||||
Disease Associations | |||||
Tissue Specificity | Isoform 1 is expressed at high level in brain, skeletal muscle, testis, bone, calvaria, osteoblasts and leukocytes. Expressed at intermediate level in liver, heart, kidney and spleen. Expressed at low level in lung, pancreas, placenta and ovary. Not detected in thymus, prostate, small intestine, tongue and colon. Isoform 1 and isoform 2 are expressed in kidney at the same level. Isoform 2 is expressed at lower level than isoform 1 in the other tissues. {ECO:0000269PubMed:15194188}. | ||||
Comments | |||||
Interactions | |||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||
PDB ID | |||||
InterPro |
IPR000337
GPCR, family 3 IPR001828 Extracellular ligand-binding receptor IPR011500 GPCR, family 3, nine cysteines domain IPR017978 GPCR, family 3, C-terminal IPR028082 Periplasmic binding protein-like I |
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PFAM |
PF01094
PF07562 PF00003 |
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PRINTS |
PR00248
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PIRSF | |||||
SMART | |||||
TIGRFAMs | |||||
Post-translational Modifications | |||||
Modification | |||||
Cross-References | |||||
SwissProt | Q5T6X5 | ||||
PhosphoSite | PhosphoSite-Q5T6X5 | ||||
TrEMBL | |||||
UniProt Splice Variant | |||||
Entrez Gene | 222545 | ||||
UniGene | Hs.266745 | ||||
RefSeq | NP_001273283 | ||||
HUGO | HGNC:18510 | ||||
OMIM | 613572 | ||||
CCDS | CCDS69185 | ||||
HPRD | 17074 | ||||
IMGT | |||||
EMBL | AB065680 AB083615 AF502962 AL354716 AY435125 AY435126 AY435127 | ||||
GenPept | AAM22230 AAS13465 AAS13466 AAS13467 BAB89328 BAC05904 CAI16922 | ||||