InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: GLRX3

Summary

InnateDB Protein

IDBP-602859.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GLRX3

Protein Name

glutaredoxin 3

Synonyms

GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3;

Species

Homo sapiens

Ensembl Protein

ENSP00000435445

InnateDB Gene

IDBG-93235 (GLRX3)

Protein Structure

UniProt Annotation

Function

Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Crucial regulator of cellular iron homeostasis and hemoglobin maturation. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. {ECO:0000250, ECO:0000269PubMed:23615448}.

Subcellular Localization

Cytoplasm, cell cortex {ECO:0000269PubMed:10636891}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area. In the Z line, found associated with CSRP3 (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	37 [view]
Protein-Protein	37 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0044822	poly(A) RNA binding
GO:0046872	metal ion binding
GO:0051536	iron-sulfur cluster binding

Biological Process

GO:0002026	regulation of the force of heart contraction
GO:0007067	mitotic nuclear division
GO:0010614	negative regulation of cardiac muscle hypertrophy
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005681	spliceosomal complex
GO:0005938	cell cortex
GO:0030018	Z disc
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR002109 Glutaredoxin
IPR004123 mRNA splicing factor, thioredoxin-like U5 snRNP
IPR004480 Monothiol glutaredoxin-related
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
IPR024253 Phosducin, thioredoxin-like domain

PFAM