Version 5.4
Homo sapiens Gene: GLRX3
Summary
InnateDB Gene IDBG-93235.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GLRX3
Gene Name glutaredoxin 3
Synonyms GLRX4; GRX3; GRX4; PICOT; TXNL2; TXNL3
Species Homo sapiens
Ensembl Gene ENSG00000108010
Encoded Proteins
IDBP-93239
glutaredoxin 3
IDBP-93241
glutaredoxin 3
IDBP-602859
glutaredoxin 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the glutaredoxin family. Glutaredoxins are oxidoreductase enzymes that reduce a variety of substrates using glutathione as a cofactor. The encoded protein binds to and modulates the function of protein kinase C theta. The encoded protein may also inhibit apoptosis and play a role in cellular growth, and the expression of this gene may be a marker for cancer. Pseudogenes of this gene are located on the short arm of chromosomes 6 and 9. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:130136399-130184521
Strand Forward strand
Band q26.3
Transcripts
ENST00000368644 ENSP00000357633
ENST00000331244 ENSP00000330836
ENST00000481034 ENSP00000435445
ENST00000486974
ENST00000496195
ENST00000619341
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein-Protein 37 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0009055 electron carrier activity
GO:0015035 protein disulfide oxidoreductase activity
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0051536 iron-sulfur cluster binding
Biological Process
GO:0002026 regulation of the force of heart contraction
GO:0007067 mitotic nuclear division
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005681 spliceosomal complex
GO:0005938 cell cortex
GO:0030018 Z disc
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031068
View Gene Order
ENSBTAG00000005027
Not yet available
Cross-References
SwissProt O76003
TrEMBL
UniProt Splice Variant
Entrez Gene 10539
UniGene Hs.42644 Hs.603031
RefSeq NM_001199868 NM_006541
HUGO HGNC:15987
OMIM 612754
CCDS CCDS7661
HPRD 10153
IMGT
EMBL AF118649 AF118652 AJ010841 AK021926 AK022131 AL139123 BC005289 BC014372 CH471066
GenPept AAF28841 AAF28844 AAH05289 AAH14372 BAG51059 BAG51067 CAA09375 CAC40691 EAW49152 EAW49154 EAW49155
RNA Seq Atlas 10539

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca