InnateDB Protein
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IDBP-602916.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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CRTAM
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Protein Name
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cytotoxic and regulatory T cell molecule
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000433728
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InnateDB Gene
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IDBG-74801 (CRTAM)
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Protein Structure
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Function |
Interaction with CADM1 promotes natural killer (NK) cell cytotoxicity and interferon-gamma (IFN-gamma) secretion by CD8+ cells in vitro as well as NK cell-mediated rejection of tumors expressing CADM3 in vivo. {ECO:0000250UniProtKB:Q149L7, ECO:0000269PubMed:15811952}.
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Subcellular Localization |
Membrane {ECO:0000255}; Single-pass type I membrane protein {ECO:0000255}.
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Disease Associations |
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Tissue Specificity |
In the immune system, expression is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. Strongly expressed in spleen, thymus, small intestine, peripheral blood leukocyte, and in Purkinje neurons in cerebellum. Expressed at much lower levels in testis, ovary, colon, lung and lymphoid tissues. {ECO:0000269PubMed:10811014, ECO:0000269PubMed:15811952, ECO:0000269PubMed:16300832}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
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Protein-Protein |
1
[view]
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Protein-DNA |
2
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
GO:0002355
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detection of tumor cell
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GO:0002860
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positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
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GO:0008037
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cell recognition
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GO:0045954
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positive regulation of natural killer cell mediated cytotoxicity
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GO:0050715
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positive regulation of cytokine secretion
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GO:0050776
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regulation of immune response
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GO:0051606
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detection of stimulus
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Cellular Component |
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PDB ID |
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InterPro |
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
O95727
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PhosphoSite |
PhosphoSite-O95727
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56253
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UniGene |
Hs.159523
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RefSeq |
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HUGO |
HGNC:24313
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OMIM |
612597
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CCDS |
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HPRD |
16760
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IMGT |
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EMBL |
AB209830
AF001622
BC070266
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GenPept |
AAC80267
AAH70266
BAD93067
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