Version 5.4
Homo sapiens Gene: CRTAM
Summary
InnateDB Gene IDBG-74801.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CRTAM
Gene Name cytotoxic and regulatory T cell molecule
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000109943
Encoded Proteins
IDBP-74803
cytotoxic and regulatory T cell molecule
IDBP-602916
cytotoxic and regulatory T cell molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The CRTAM gene is upregulated in CD4 (see MIM 186940)-positive and CD8 (see CD8A; MIM 186910)-positive T cells and encodes a type I transmembrane protein with V and C1-like Ig domains (Yeh et al., 2008 [PubMed 18329370]).[supplied by OMIM, Feb 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:122838500-122872639
Strand Forward strand
Band q24.1
Transcripts
ENST00000227348 ENSP00000227348
ENST00000533709 ENSP00000433728
ENST00000533416
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 1 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0002355 detection of tumor cell
GO:0002860 positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0008037 cell recognition
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity
GO:0050715 positive regulation of cytokine secretion
GO:0050776 regulation of immune response
GO:0051606 detection of stimulus
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032021
View Gene Order
ENSBTAG00000005193
Not yet available
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O95727
TrEMBL
UniProt Splice Variant
Entrez Gene 56253
UniGene Hs.159523
RefSeq NM_019604
HUGO HGNC:24313
OMIM 612597
CCDS CCDS8437
HPRD
IMGT
EMBL AB209830 AF001622 BC070266
GenPept AAC80267 AAH70266 BAD93067
RNA Seq Atlas 56253

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca